가토의 측두하악관절원판 결손에서 간세포 성장인자가 치유에 미치는 영향
Effect of hepatocyte growth factor on the repair of defect in the articular disc in rabbit temporomandibular joint
김복주, 김규천, 김철훈, 성화식, 신상훈, 황희성,
소속 상세정보
김복주 ( Kim Bok-Joo ) - 동아대학교의료원 치과학교실 구강악안면외과
김규천 ( Kim Gyoo-Cheon ) - 부산대학교 치의학전문대학원 구강해부학교실
김철훈 ( Kim Cheol-Hun ) - 동아대학교병원 구강악안면외과
성화식 ( Seong Hwa-Sik ) - 부산대학교 치과대학 구강악안면외과학교실
신상훈 ( Shin Sang-Hun ) - 동아대학교의료원 치과학교실 구강악안면외과
황희성 ( Hwang Hee-Seong ) - 동아대학교의료원 치과학교실 구강악안면외과
KMID : 0360120090310010001
Abstract
Purpose: The purpose of this study is to investigate the therapeutic use of Hepatocyte growth factor(Adv.CMV.HGF) in temporomandibular joint disc defect.
Materials and Methods: Twelve New Zealand white rabbits, weighing 2.5 - 3.0 kg, were used in this experiment. Defects(2 mm in diameter) were created in their TMJ discs. Recombinant Adv.CMV.HGF with gelatin sponge(Gelfoam(R)) as carrier was implanted in the defects. We divided the rabbits into four batches according to the duration of the implantation - of 1, 4, 8, 12 weeks - and both left and right TMJ of each rabbit in all groups were used in the research : left joints were used as experiment group and right were control group. Each batch of rabbits was killed one, four, eight and twelve weeks after the experimentation respectively, and called Group A, B, C, and D. (Group A = 1 wk, B = 4 wks, C = 8 wks, and D = 12 wks)
Results: The experimental group showed a significant increase in the number of chondroblasts and active cell differentiation at the margin of the defects. Compared to the control group, in the experiment group chondroblasts increased and chondrocytes showed a columnar arrangement, which is witnessed at the time of cell differentiation.
conclusion: This study supports the case that Avd.CMV.HGF may be useful in the repair of articular disc of the rabbit TMJ.
키워드
Hepatocyte growth factor;Articular disc;Repair of defect
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